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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P08567




USC-OGP 2-DE database:  P08567


P08567


General information about the entry
View entry in simple text format
Entry namePLEK_HUMAN
Primary accession numberP08567
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Pleckstrin; AltName: Full=Platelet 47 kDa protein; Short=p47;.
Gene nameName=PLEK
Synonyms=P47
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.99; Mw=45106
pI=6.01; Mw=44886
pI=6.41; Mw=42022
pI=6.74; Mw=42022
pI=6.64; Mw=41919
pI=6.45; Mw=41817
pI=6.49; Mw=41817
pI=6.59; Mw=41613
pI=6.18; Mw=41512



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.74; Mw=43223
pI=5.98; Mw=42057
pI=5.96; Mw=41952



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info
 
PLATELET_6-11

MAP LOCATIONS:
pI=6.20; Mw=42300
pI=6.13; Mw=42101
pI=6.51; Mw=42101
pI=6.38; Mw=42003
pI=6.62; Mw=41904
pI=7.14; Mw=41904
pI=7.28; Mw=41904
pI=6.88; Mw=41806
pI=6.98; Mw=41806
pI=7.05; Mw=41806
pI=7.21; Mw=41806
pI=7.32; Mw=41806

Cross-references
UniProtKB/Swiss-ProtP08567; PLEK_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry namePLEK_HUMAN
Primary accession numberP08567
Secondary accession number(s) B2R9E8 Q53SU8 Q6FGM8 Q6FGQ1 Q8WV81
Sequence was last modified on January 11, 2011 (version 3)
Annotations were last modified on March 15, 2017 (version 182)
Name and origin of the protein
DescriptionRecName: Full=Pleckstrin; AltName: Full=Platelet 47 kDa protein; Short=p47;
Gene nameName=PLEK
Synonyms=P47
Encoded onName=PLEK; Synonyms=P47
Keywords3D-structure; Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX07743; CAA30564.1; -; mRNA
EMBLCR542056; CAG46853.1; -; mRNA
EMBLCR542079; CAG46876.1; -; mRNA
EMBLAK313756; BAG36495.1; -; mRNA
EMBLAC015969; AAX93121.1; -; Genomic_DNA
EMBLCH471053; EAW99876.1; -; Genomic_DNA
EMBLBC018549; AAH18549.1; -; mRNA
CCDSCCDS1887.1; -; .
PIRS00755; S00755; .
RefSeqNP_002655.2; NM_002664.2; .
UniGeneHs.468840; -; .
PDB1PLS; NMR; -; A=1-105
PDB1W4M; NMR; -; A=121-223
PDB1X05; NMR; -; A=235-350
PDB1XX0; NMR; -; A=234-350
PDB1ZM0; X-ray; 2.10 A; A/B=240-350
PDB2CSO; NMR; -; A=116-229
PDB2I5C; X-ray; 1.75 A; A/B/C=244-347
PDB2I5F; X-ray; 1.35 A; A=244-347
PDBsum1PLS; -; .
PDBsum1W4M; -; .
PDBsum1X05; -; .
PDBsum1XX0; -; .
PDBsum1ZM0; -; .
PDBsum2CSO; -; .
PDBsum2I5C; -; .
PDBsum2I5F; -; .
ProteinModelPortalP08567; -; .
SMRP08567; -; .
BioGrid111357; 2; .
IntActP08567; 10; .
MINTMINT-8216753; -; .
STRING9606.ENSP00000234313; -; .
iPTMnetP08567; -; .
PhosphoSitePlusP08567; -; .
BioMutaPLEK; -; .
DMDM317373523; -; .
OGPP08567; -; .
EPDP08567; -; .
MaxQBP08567; -; .
PaxDbP08567; -; .
PeptideAtlasP08567; -; .
PRIDEP08567; -; .
DNASU5341; -; .
EnsemblENST00000234313; ENSP00000234313; ENSG00000115956; .
GeneID5341; -; .
KEGGhsa:5341; -; .
UCSCuc002sen.5; human; .
CTD5341; -; .
DisGeNET5341; -; .
GeneCardsPLEK; -; .
H-InvDBHIX0002122; -; .
HGNCHGNC:9070; PLEK; .
HPAHPA031838; -; .
MIM173570; gene; .
neXtProtNX_P08567; -; .
OpenTargetsENSG00000115956; -; .
PharmGKBPA33400; -; .
eggNOGENOG410IFJ7; Eukaryota; .
eggNOGENOG410ZY9B; LUCA; .
GeneTreeENSGT00390000006543; -; .
HOGENOMHOG000294078; -; .
HOVERGENHBG001361; -; .
InParanoidP08567; -; .
KOK19993; -; .
OMAFCEGYSS; -; .
OrthoDBEOG091G09EY; -; .
PhylomeDBP08567; -; .
TreeFamTF332246; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
SIGNORP08567; -; .
ChiTaRSPLEK; human; .
EvolutionaryTraceP08567; -; .
GenomeRNAi5341; -; .
PROPR:P08567; -; .
ProteomesUP000005640; Chromosome 2; .
BgeeENSG00000115956; -; .
CleanExHS_PLEK; -; .
GenevisibleP08567; HS; .
GOGO:0005737; C:cytoplasm; IDA:BHF-UCL; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0032587; C:ruffle membrane; IDA:BHF-UCL; .
GOGO:0043325; F:phosphatidylinositol-3; 4-bisphosphate binding; IDA:BHF-UCL
GOGO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; .
GOGO:0005080; F:protein kinase C binding; IDA:BHF-UCL; .
GOGO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL; .
GOGO:0030030; P:cell projection organization; IDA:BHF-UCL; .
GOGO:0030866; P:cortical actin cytoskeleton organization; IDA:BHF-UCL; .
GOGO:0002244; P:hematopoietic progenitor cell differentiation; IEP:BHF-UCL; .
GOGO:0007229; P:integrin-mediated signaling pathway; IDA:BHF-UCL; .
GOGO:0050849; P:negative regulation of calcium-mediated signaling; NAS:BHF-UCL; .
GOGO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IDA:BHF-UCL; .
GOGO:0010920; P:negative regulation of inositol phosphate biosynthetic process; IDA:BHF-UCL; .
GOGO:0046488; P:phosphatidylinositol metabolic process; IDA:BHF-UCL; .
GOGO:0030845; P:phospholipase C-inhibiting G-protein coupled receptor signaling pathway; IDA:BHF-UCL; .
GOGO:0070527; P:platelet aggregation; IMP:UniProtKB; .
GOGO:0002576; P:platelet degranulation; IEP:BHF-UCL; .
GOGO:0032233; P:positive regulation of actin filament bundle assembly; IDA:BHF-UCL; .
GOGO:0030836; P:positive regulation of actin filament depolymerization; IDA:BHF-UCL; .
GOGO:0010925; P:positive regulation of inositol-polyphosphate 5-phosphatase activity; IDA:BHF-UCL; .
GOGO:0033625; P:positive regulation of integrin activation; ISS:BHF-UCL; .
GOGO:0010572; P:positive regulation of platelet activation; ISS:BHF-UCL; .
GOGO:0070528; P:protein kinase C signaling; ISS:BHF-UCL; .
GOGO:0070560; P:protein secretion by platelet; ISS:BHF-UCL; .
GOGO:0060305; P:regulation of cell diameter; IDA:BHF-UCL; .
GOGO:0031529; P:ruffle organization; IDA:BHF-UCL; .
GOGO:0070493; P:thrombin-activated receptor signaling pathway; IDA:BHF-UCL; .
GOGO:0006904; P:vesicle docking involved in exocytosis; ISS:BHF-UCL; .
Gene3D1.10.10.10; -; 1; .
Gene3D2.30.29.30; -; 2; .
InterProIPR000591; DEP_dom; .
InterProIPR011993; PH_dom-like; .
InterProIPR001849; PH_domain; .
InterProIPR011991; WHTH_DNA-bd_dom; .
PfamPF00610; DEP; 1; .
PfamPF00169; PH; 2; .
SMARTSM00049; DEP; 1; .
SMARTSM00233; PH; 2; .
SUPFAMSSF46785; SSF46785; 1; .
SUPFAMSSF50729; SSF50729; 2; .
PROSITEPS50186; DEP; 1; .
PROSITEPS50003; PH_DOMAIN; 2; .



USC-OGP 2-DE database image


Gateways to other related servers


Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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